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The National Institutes of Health (NIH) National Library of Medicine® (NLM) undertook an 18-month project to evaluate, test and recommend digital repository software and systems to support NLM's collection and preservation of a wide variety of digital objects. This article outlines the methodology NLM used to analyze the landscape of repository software and select three systems for in-depth testing. Finally, the article discusses the evaluation results and next steps for NLM. This project followed an earlier NLM working group, which created functional requirements and identified key policy issues for an NLM digital repository to aid in building NLM's collection in the digital environment.